Causes of Acne
There are four main factors that lead to the development of acne.
- The presence of Cutibacterium acnes (C acnes) in the sebaceous follicle
- Androgen-mediated increase in sebum production
- Keratinocyte hyperproliferation in the follicle
- Inflammation
Other risk factors for acne include:
- Genetic factors
- Psychological stress
- Hormonal factors (eg. polycystic ovaries, puberty & pregnancy)
- Medications (eg. topical corticosteroids, anti-epileptics)
- Dairy and high glycemic index diets